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Image Search Results
Journal: PLoS ONE
Article Title: Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms
doi: 10.1371/journal.pone.0018525
Figure Lengend Snippet: Wild-type (IL-6 +/+ ) and IL-6 −/− mice were exposed contemporaneously to CAPs (PM 2.5 ) or filtered air (FA) for 8 hours daily on 3 consecutive days and BAL fluid was harvested at the end of the third day of exposure for measurement of Interleukin-6 (IL-6) ( A ), Monocyte Chemotactic Protein-1 (MCP-1) ( B ) and Tumor Necrosis Factor-α (TNF-α) ( C ). White adipose tissue was harvested from identically treated mice for measurement of the levels of PAI-1 mRNA ( D ). Wild type mice were treated with etanercept (10 mg/kg i.p.) or vehicle (saline) 3 days before and on the first day of exposure to CAPs or FA and white adipose tissue levels of PAI-1 mRNA were measured after the third day of exposure ( E ). (*p<0.05 CAPs vs. FA, n≥6/group).
Article Snippet: We measured PT, PTT, and plasma TAT levels as previously described and
Techniques:
Journal: PLoS ONE
Article Title: Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms
doi: 10.1371/journal.pone.0018525
Figure Lengend Snippet: Wild-type (IL-6 +/+ ) and IL-6 −/− mice were treated with PM (200 µg/mouse) or PBS and lung and white adipose tissues, BAL fluid and plasma were harvested 24 hours later. ( A ) Whole lung PAI-1 mRNA, ( B ) BAL fluid PAI-1 antigen, ( C ) adipose tissue PAI-1 mRNA and ( D ) BAL fluid TNF-α levels were measured. Wild-type mice were treated with either etanercept, a TNF-α inhibitor (10 mg/kg i.p.) or vehicle (saline) 3 days and on the day of exposure to PM (200 µg/mouse) or PBS and BAL fluid, white adipose tissue and plasma were harvested or a bleeding time after tail vein cut performed 24 hours later. BAL fluid PAI-1 antigen ( E ), white adipose tissue PAI-1 mRNA ( F ), bleeding time after tail vein cut ( G ), plasma prothrombin time (PT) ( H ), partial thromboplastin time (PTT) ( I ) and plasma thrombin-antithrombin (TAT) complexes ( J ) were measured. (p<0.05, *PM vs. PBS, n≥4/group).
Article Snippet: We measured PT, PTT, and plasma TAT levels as previously described and
Techniques: